003025 - Fmr1 KO Strain Details - The Jackson Laboratory
WEB003025 B6.129P2-<i>Fmr1<sup>tm1Cgr</sup></i>/J These <i>Fmr1</i> knockout mice may be useful in applications related to the study of Fragile X Syndrome.
Multi-level profiling of the Fmr1 KO rat unveils altered behavioral ...
WEBFeb 20, 2024 · Although the knockout (KO) of the Fmr1 gene homolog in mice is primarily used for elucidating the neurobiological substrate of FXS, there is limited association of the experimental data...
Modeling fragile X syndrome in the Fmr1 knockout mouse
WEBOct 31, 2014 · The most well characterized rodent model is the Fmr1 knockout (KO) mouse, which lacks FMRP protein due to a disruption in its Fmr1 gene. Here, we review the behavioral phenotyping of the Fmr1 KO mouse to date, and discuss the clinical relevance of this mouse model to the human FXS condition.
Fmr1 knockout mice: a model to study fragile X mental ... - PubMed
WEBJul 15, 1994 · The absence of FMR1 protein leads to mental retardation, aberrant behavior, and macroorchidism. Hardly anything is known about the physiological function of FMR1 and the pathological mechanisms leading to these symptoms. Therefore, we designed a knockout model for the fragile X syndrome in mice.
Increased body weight in mice with fragile X messenger ... - Nature
WEBAug 4, 2023 · In the current study, we determined that male Fmr1 knockout mice (KO, Fmr1 −/y), but not female Fmr1 −/−, exhibit increased weight when compared to wild-type controls, similarly to humans ...
The molecular biology of FMRP: new insights into fragile X ... - Nature
WEBFeb 19, 2021 · A chromatin immunoprecipitation experiment followed by DNA sequencing showed that the trimethylation of lysine 36 on histone H3 landscape was altered in the hippocampus of Fmr1-knockout mice.
Mouse models of fragile X-related disorders - PMC - National …
WEBFeb 2, 2023 · The transgenic mice were also intercrossed with an Fmr1 KO mouse, which led to the rescue or even ‘overcorrection’ of the anatomical and behavioral abnormalities observed in the KO model (Peier et al., 2000).
Altered cortical Cytoarchitecture in the Fmr1 knockout mouse
WEBJun 14, 2019 · Fmr1 KO mice show significantly more oligodendrocytes and enhanced myelination in the cortex. a Representative fluorescent images of Olig2 immunostaining of WT and Fmr1 KO brain coronal sections delineating the …
004624 - Fmr1 KO Strain Details - The Jackson Laboratory
WEB004624 FVB.129P2- Pde6b + Tyr c-ch Fmr1 tm1Cgr /J Fmr1 -knockout ( Fmr1 -KO) mice may be useful for studying behavioral and synaptic abnormalities associated with Fragile X Syndrome.
The generation of a conditional Fmr1 knock out mouse model to …
WEBThe FMR1 gene, mutated in Fragile X syndrome patients, has been modeled in mice with a neomycin cassette inserted in exon 5 of the mouse Fmr1 gene creating an Fmr1 knockout (Fmr1 KO) allele. This results in animals lacking Fmr1 protein (Fmrp) expression in …