Rybp orchestrates spermatogenesis via regulating meiosis and …
WEBIn this study, we used Rybp conditional knockout mouse model to genetically ablate Rybp in male germ cells. We found that Rybp deficiency during spermatogenesis led to smaller testes, loss of germline cells, disturbed meiosis, increased apoptosis of spermatocytes, decreased sperm motility, and reduced global H3K9me3, without impacting ...
RYBP regulates Pax6 during in vitro neural differentiation of …
WEBFeb 11, 2022 · We have previously reported that RING1 and YY1 binding protein (RYBP) is important for central nervous system development in mice and that Rybp null mutant (Rybp−/−) mouse embryonic stem...
Rybp orchestrates spermatogenesis via regulating meiosis and …
WEBApr 23, 2020 · We found that Rybp conditional knockout (cKO) mice had smaller testes, apoptosis of leptotene to zygotene spermatocytes, less germ cells per tubule, and reduced sperm motility, indicating that RYBP plays important roles during mammalian spermatogenesis.
Functional dissection of PRC1 subunits RYBP and YAF2 during …
WEBNov 7, 2023 · Rybp knockout impairs neural differentiation by activating Wnt signaling and derepressing nonneuroectoderm-associated genes.
Germ-cell-specific Rybp-knockout mice were fertile. (A) …
WEBContext 1. ... explore whether Rybp plays a functional role in germ-cell differentiation and meiosis, we conditionally deleted Rybp in fetal gonocytes on embryonic day (E) 14.5 by crossing...
RYBP regulates Pax6 during in vitro neural differentiation of …
WEBFeb 11, 2022 · These results suggest polycomb dependent regulation of Pax6 by RYBP during in vitro neural differentiation. Our results thus provide novel insights on the dynamic regulation of Pax6 and RA signaling by RYBP during mouse neural development.
Epigenetic and non-epigenetic functions of the RYBP protein in ...
WEBSep 1, 2018 · A role of RYBP/dRYBP in apoptosis is observed when analysing the effect of the modulation of its levels both in vertebrates and flies. Knockout RYBP mice embryos do not complete decidualization, a developmental process for which apoptosis is required (Bian et al., 2016; Pirity et al., 2005).
Ring 1 and YY1 Binding Protein is Expressed in Murine ... - MDPI
WEBOur results showed that, although Rybp was expressed in murine spermatocytes and the expression of several meiosis-related genes was significantly reduced in Ddx4-Cre +; Rybp flox/flox (designated hereafter as Rybp-cKO) mice, Rybp was not required for spermatogenesis.
RYBP modulates embryonic neurogenesis involving the Notch …
WEBDec 14, 2021 · To examine the function of RYBP in regulating embryonic neurogenesis in vivo, we performed in utero electroporation (IUE) to deliver scramble and shRybp plasmids into the brain of E14 embryonic mice, respectively, which …
WEBOur results thus provide novel insights on the dynamic regulation of Pax6 and RA signaling by RYBP during mouse neural development. Signaling by the retinoic acid (RA) pathway is crucial for ...