Carbondale is a city in Jackson County, Illinois, United States, within the Southern Illinois region informally known as "Little Egypt". As of the 2…Carbondale is a city in Jackson County, Illinois, United States, within the Southern Illinois region informally known as "Little Egypt". As of the 2020 census, the city had a population of 25,083, making it the most populous city in Southern Illinois outside the Metro East region of Greater St. Louis.
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